{
  "version": "https://jsonfeed.org/version/1.1",
  "title": "AevaWire Longevity Feed",
  "home_page_url": "https://aevawire.com",
  "feed_url": "https://aevawire.com/feed.json",
  "description": "Continuous hourly dispatches covering geroscience and AI biological discovery.",
  "items": [
    {
      "id": "pmid:42079114",
      "url": "https://doi.org/10.64898/2026.04.18.719358",
      "title": "Adulthood depletion of Integrator extends lifespan and healthspan via defective pre-mRNA processing",
      "summary": "Peer-reviewed telemetry published in bioRxiv. Categorized under Geroscience.",
      "date_published": "2026-09-24T10:47:42.172546+00:00",
      "phase": "Computational / Theoretical",
      "tags": [
        "Geroscience"
      ],
      "source": "bioRxiv",
      "evidence_confidence": "High"
    },
    {
      "id": "pmid:42232577",
      "url": "https://doi.org/10.3389/fnut.2026.1775264",
      "title": "Glycine and N-acetylcysteine supplementation, with or without exercise, in brain health and functional aging: implications for sarcopenia and frailty in older adults",
      "summary": "Peer-reviewed telemetry published in Front Nutr. Categorized under Geroscience.",
      "date_published": "2026-09-24T10:47:42.172546+00:00",
      "phase": "Computational / Theoretical",
      "tags": [
        "Geroscience"
      ],
      "source": "Front Nutr",
      "evidence_confidence": "High"
    },
    {
      "id": "pmid:42365207",
      "url": "https://doi.org/10.1007/s10522-026-10463-8",
      "title": "A multi-ingredient food supplement slows age-dependent decline of mobility and influences gene expression in C. elegans",
      "summary": "Peer-reviewed telemetry published in Biogerontology. Categorized under Geroscience.",
      "date_published": "2026-09-24T10:47:42.172546+00:00",
      "phase": "Computational / Theoretical",
      "tags": [
        "Geroscience"
      ],
      "source": "Biogerontology",
      "evidence_confidence": "High"
    },
    {
      "id": "pmid:42398771",
      "url": "https://doi.org/10.1016/j.arr.2026.103227",
      "title": "Systemic recalibration and epigenetic resetting as complementary strategies in ageing biology",
      "summary": "Peer-reviewed telemetry published in Ageing Res Rev. Categorized under Epigenetic Reprogramming.",
      "date_published": "2026-09-24T10:47:40.599862+00:00",
      "phase": "Computational / Theoretical",
      "tags": [
        "Epigenetic Reprogramming"
      ],
      "source": "Ageing Res Rev",
      "evidence_confidence": "High"
    },
    {
      "id": "pmid:42527762",
      "url": "https://doi.org/10.1007/s12015-026-11197-3",
      "title": "Harnessing Endogenous Plasticity Rather than Reprogramming of Mature Cells Will Advance Regenerative Medicine, Cancer Treatment and Rejuvenation",
      "summary": "Peer-reviewed telemetry published in Stem Cell Rev Rep. Categorized under Epigenetic Reprogramming.",
      "date_published": "2026-09-24T10:47:40.599862+00:00",
      "phase": "Mechanistic (In Vitro)",
      "tags": [
        "Epigenetic Reprogramming"
      ],
      "source": "Stem Cell Rev Rep",
      "evidence_confidence": "High"
    },
    {
      "id": "pmid:42636097",
      "url": "https://doi.org/10.1152/ajpheart.00417.2026",
      "title": "Role of epigenetic factors during blockade of the renin-angiotensin system across aging",
      "summary": "Peer-reviewed telemetry published in Am J Physiol Heart Circ Physiol. Categorized under Epigenetic Reprogramming.",
      "date_published": "2026-09-24T10:47:40.599862+00:00",
      "phase": "Computational / Theoretical",
      "tags": [
        "Epigenetic Reprogramming"
      ],
      "source": "Am J Physiol Heart Circ Physiol",
      "evidence_confidence": "High"
    },
    {
      "id": "pmid:42537808",
      "url": "https://doi.org/10.1016/j.arr.2026.103283",
      "title": "The Physical Senotype in cellular senescence: Mechanical and physical strategies for senotherapy",
      "summary": "Peer-reviewed telemetry published in Ageing Res Rev. Categorized under Senotherapeutics.",
      "date_published": "2026-09-24T10:47:38.538410+00:00",
      "phase": "Mechanistic (In Vitro)",
      "tags": [
        "Senotherapeutics"
      ],
      "source": "Ageing Res Rev",
      "evidence_confidence": "High"
    },
    {
      "id": "pmid:42448061",
      "url": "https://doi.org/10.1016/j.freeradbiomed.2026.07.019",
      "title": "Resveratrol exerts anti-aging effects in young but pro-aging effects in middle-aged C. elegans via a gerosuppressive daf-16/dod-6/sod-3 axis",
      "summary": "Peer-reviewed telemetry published in Free Radic Biol Med. Categorized under Geroscience.",
      "date_published": "2026-09-24T10:47:38.538410+00:00",
      "phase": "Computational / Theoretical",
      "tags": [
        "Geroscience"
      ],
      "source": "Free Radic Biol Med",
      "evidence_confidence": "High"
    },
    {
      "id": "pmid:42734460",
      "url": "https://doi.org/10.4103/mgr.MEDGASRES-D-25-00163",
      "title": "Molecular hydrogen: a potential guardian against environmental radiation damage",
      "summary": "Peer-reviewed telemetry published in Med Gas Res. Categorized under Geroscience.",
      "date_published": "2026-09-24T10:47:38.538410+00:00",
      "phase": "Computational / Theoretical",
      "tags": [
        "Geroscience"
      ],
      "source": "Med Gas Res",
      "evidence_confidence": "High"
    },
    {
      "id": "pmid:42723438",
      "url": "https://doi.org/10.1080/15592294.2026.2714582",
      "title": "A breast tissue-specific epigenetic clock provides accurate chronological age predictions and reveals de-correlation of age and DNA methylation in tumor-adjacent and tumor samples",
      "summary": "Peer-reviewed telemetry published in Epigenetics. Categorized under Epigenetic Reprogramming.",
      "date_published": "2026-09-24T10:47:36.494169+00:00",
      "phase": "Computational / Theoretical",
      "tags": [
        "Epigenetic Reprogramming"
      ],
      "source": "Epigenetics",
      "evidence_confidence": "High"
    },
    {
      "id": "pmid:42391881",
      "url": "https://doi.org/10.1016/j.fsigen.2026.103579",
      "title": "Ensaya: An ensemble age model for prediction of chronological age in adolescents and young adults",
      "summary": "Peer-reviewed telemetry published in Forensic Sci Int Genet. Categorized under Geroscience.",
      "date_published": "2026-09-24T10:47:36.494169+00:00",
      "phase": "Computational / Theoretical",
      "tags": [
        "Geroscience"
      ],
      "source": "Forensic Sci Int Genet",
      "evidence_confidence": "High"
    },
    {
      "id": "pmid:42757133",
      "url": "https://doi.org/10.1016/j.bioactmat.2026.07.001",
      "title": "3D-printed PCL scaffold coated with chitosan-hyaluronic acid hydrogel loaded with NGF-overexpressing UiPSC-derived neural crest cells restores erectile function via cavernous nerve regeneration",
      "summary": "Peer-reviewed telemetry published in Bioact Mater. Categorized under Geroscience.",
      "date_published": "2026-09-24T10:47:36.494169+00:00",
      "phase": "Mechanistic (In Vitro)",
      "tags": [
        "Geroscience"
      ],
      "source": "Bioact Mater",
      "evidence_confidence": "High"
    },
    {
      "id": "2026-09-24-osk-muscle-rejuvenation",
      "url": "https://aevawire.com#osk-rejuvenation",
      "title": "Epigenetic Age Reversal in Skeletal Muscle via Non-Viral Yamanaka OSK Delivery",
      "summary": "Stanford-led team demonstrates 42% restoration of muscle regenerative capacity in 24-month-old mice using lipid nanoparticles targeted to satellite cells.",
      "date_published": "2026-09-24T10:00:00Z",
      "tags": [
        "OSK Reprogramming",
        "Epigenetic Clocks",
        "LNP"
      ],
      "_confidence_score": 0.94
    },
    {
      "id": "2026-09-24-alphafold-senolytics",
      "url": "https://aevawire.com#alphafold-senolytics",
      "title": "AlphaFold-Genomics Predicts De Novo Peptide Senolytics Targeting BCL-xL",
      "summary": "Computational screening of over 1.4 million peptide conformations yields three high-affinity candidates targeting senescent cells with low platelet toxicity.",
      "date_published": "2026-09-24T08:00:00Z",
      "tags": [
        "Senolytics",
        "AlphaFold",
        "BCL-xL"
      ],
      "_confidence_score": 0.91
    }
  ]
}